HIGHLIGHTED TOPIC Regulation of the Cerebral Circulation Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms
نویسندگان
چکیده
Rhonda D. Prisby, M. Keith Wilkerson, Elke M. Sokoya, Robert M. Bryan, Jr., Emily Wilson, and Michael D. Delp Division of Exercise Physiology and Department of Physiology and Pharmacology, and Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia; Department of Pharmacology, University of Vermont College of Medicine, Burlington, Vermont; Department of Anesthesiology, Baylor College of Medicine, Houston, Texas; and Department of Medical Physiology and the Cardiovascular Research Institute, Texas A&M University Health Science Center, College Station, Texas
منابع مشابه
Mechanisms of endothelial P2Y1- and P2Y2-mediated vasodilatation involve differential [Ca]i responses
Marrelli, Sean P. Mechanisms of endothelial P2Y1and P2Y2-mediated vasodilatation involve differential [Ca]i responses. Am J Physiol Heart Circ Physiol 281: H1759–H1766, 2001.—The present study was designed to evaluate the role of endothelial intracellular Ca21 concentration ([Ca]i) in the difference between P2Y1and P2Y2-mediated vasodilatations in cerebral arteries. Rat middle cerebral arteries...
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Adaptation of the cerebral circulation to microgravity was investigated in rat middle cerebral arteries after 20 days of hindlimb unweighting (HU). Myogenic responses were measured in isolated, pressurized arteries from HU and control animals. Maximal passive lumen diameters, obtained in the absence of extracellular Ca2+ plus EDTA, were not significantly different between groups (249 vs. 258 mi...
متن کاملMechanisms of endothelial P2Y(1)- and P2Y(2)-mediated vasodilatation involve differential [Ca2+]i responses.
The present study was designed to evaluate the role of endothelial intracellular Ca(2+) concentration ([Ca(2+)](i)) in the difference between P2Y(1)- and P2Y(2)-mediated vasodilatations in cerebral arteries. Rat middle cerebral arteries were cannulated, pressurized, and luminally perfused. The endothelium was selectively loaded with fura 2, a fluorescent Ca(2+) indicator, for simultaneous measu...
متن کاملEffects of simulated microgravity on arterial nitric oxide synthase and nitrate and nitrite content.
The aim of the present work was to investigate the alterations in nitric oxide synthase (NOS) expression and nitrate and nitrite (NOx) content of different arteries from simulated microgravity rats. Male Wistar rats were randomly assigned to either a control group or simulated microgravity group. For simulating microgravity, animals were subjected to hindlimb unweighting (HU) for 20 days. Diffe...
متن کاملAngiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor.
The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin...
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تاریخ انتشار 2006